Drug interactions
Dichlorphenamide + Piperacillin-tazobactam
Severity: Moderate
Dichlorphenamide and Piperacillin-tazobactam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use may produce clinically significant hypokalemia. Dichlorphenamide promotes renal potassium loss and piperacillin, given as a sodium salt in high doses, can cause hypokalemia as well. Arrhythmia risk rises when potassium is low.
What this interaction means in plain words
Dichlorphenamide and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Piperacillin-tazobactam belongs to Anti Bacterial.
Why it happens
Additive potassium-lowering effects through increased renal potassium excretion.
What to do
Check serum potassium before and during co-therapy and replace potassium as needed. Monitor ECG in patients with heart disease or other arrhythmia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin-tazobactam
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Dichlorphenamide and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use may produce clinically significant hypokalemia. Dichlorphenamide promotes renal potassium loss and piperacillin, given as a sodium salt in high doses, can cause hypokalemia as well. Arrhythmia risk rises when potassium is low.
How serious is the interaction between Dichlorphenamide and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before and during co-therapy and replace potassium as needed. Monitor ECG in patients with heart disease or other arrhythmia risks.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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