Drug interactions
Dichlorphenamide + Romidepsin
Severity: Moderate
Dichlorphenamide and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers potassium and can cause acidosis. Romidepsin can cause electrolyte abnormalities including hypokalemia and has ECG effects including QT changes. Low potassium may increase the risk of arrhythmia.
What this interaction means in plain words
Dichlorphenamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia, which may increase susceptibility to romidepsin-related repolarization changes.
What to do
Check potassium and magnesium before and during treatment and keep potassium within normal range. Consider ECG monitoring in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Romidepsin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers potassium and can cause acidosis. Romidepsin can cause electrolyte abnormalities including hypokalemia and has ECG effects including QT changes. Low potassium may increase the risk of arrhythmia.
How serious is the interaction between Dichlorphenamide and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during treatment and keep potassium within normal range. Consider ECG monitoring in patients at risk.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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