Drug interactions
Dichlorphenamide + Sodium nitroprusside
Severity: Moderate
Dichlorphenamide and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Nitroprusside infusion, especially at high doses or prolonged use, can cause lactic acidosis through cyanide accumulation, so acid-base disturbance may be compounded.
What this interaction means in plain words
Dichlorphenamide and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive acidosis: renal bicarbonate loss from carbonic anhydrase inhibition plus cyanide-related impaired cellular respiration from nitroprusside.
What to do
Monitor blood gases, bicarbonate and lactate during nitroprusside infusion in patients on dichlorphenamide; keep nitroprusside dose and duration to a minimum and treat unexplained acidosis as possible cyanide toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Dichlorphenamide and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Nitroprusside infusion, especially at high doses or prolonged use, can cause lactic acidosis through cyanide accumulation, so acid-base disturbance may be compounded.
How serious is the interaction between Dichlorphenamide and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood gases, bicarbonate and lactate during nitroprusside infusion in patients on dichlorphenamide; keep nitroprusside dose and duration to a minimum and treat unexplained acidosis as possible cyanide toxicity.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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