Drug interactions
Dichlorphenamide + Telmisartan-amlodipine
Severity: Moderate
Dichlorphenamide and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis. Its use with telmisartan-amlodipine mainly matters because telmisartan raises potassium and may partly offset this, while hypotension and electrolyte shifts can still occur.
What this interaction means in plain words
Dichlorphenamide and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Carbonic anhydrase inhibition increases urinary bicarbonate and potassium loss, while angiotensin receptor blockade reduces potassium excretion, giving opposing electrolyte effects.
What to do
Monitor serum potassium, bicarbonate and blood pressure when starting or adjusting either drug. Correct electrolyte abnormalities as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Dichlorphenamide and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis. Its use with telmisartan-amlodipine mainly matters because telmisartan raises potassium and may partly offset this, while hypotension and electrolyte shifts can still occur.
How serious is the interaction between Dichlorphenamide and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate and blood pressure when starting or adjusting either drug. Correct electrolyte abnormalities as needed.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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