Drug interactions
Dichlorphenamide + Teniposide
Severity: Minor
Dichlorphenamide and Teniposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teniposide is a cytotoxic agent whose association with metabolic acidosis is not well established. Any additive effect with dichlorphenamide is speculative, though chemotherapy-related vomiting, diarrhea or renal injury could contribute to acid-base disturbance.
What this interaction means in plain words
Dichlorphenamide and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; possible additive acid-base disturbance.
What to do
Monitor serum bicarbonate and electrolytes during chemotherapy courses in patients taking dichlorphenamide. Reduce the dichlorphenamide dose if acidosis develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Teniposide?
MediHelp rates the interaction as minor. Dichlorphenamide and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teniposide is a cytotoxic agent whose association with metabolic acidosis is not well established. Any additive effect with dichlorphenamide is speculative, though chemotherapy-related vomiting, diarrhea or renal injury could contribute to acid-base disturbance.
How serious is the interaction between Dichlorphenamide and Teniposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes during chemotherapy courses in patients taking dichlorphenamide. Reduce the dichlorphenamide dose if acidosis develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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