Drug interactions
Dichlorphenamide + Tenofovir df
Severity: Moderate
Dichlorphenamide and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF can cause proximal renal tubulopathy with potassium, phosphate and bicarbonate wasting. Dichlorphenamide also promotes potassium loss and acidosis. Together they may worsen hypokalemia and acid-base disturbance.
What this interaction means in plain words
Dichlorphenamide and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium and bicarbonate loss via tubular effects of tenofovir and carbonic anhydrase inhibition.
What to do
Monitor serum potassium, bicarbonate, phosphate and renal function regularly. Replace potassium as needed and reassess therapy if tubular toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Tenofovir df?
MediHelp rates the interaction as moderate. Dichlorphenamide and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF can cause proximal renal tubulopathy with potassium, phosphate and bicarbonate wasting. Dichlorphenamide also promotes potassium loss and acidosis. Together they may worsen hypokalemia and acid-base disturbance.
How serious is the interaction between Dichlorphenamide and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate, phosphate and renal function regularly. Replace potassium as needed and reassess therapy if tubular toxicity develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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