Drug interactions
Dichlorphenamide + Tenofovir disoproxil
Severity: Moderate
Dichlorphenamide and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly lowers serum potassium and causes metabolic acidosis, and tenofovir tubulopathy can also cause potassium and phosphate wasting. The combination may therefore worsen hypokalemia and acid-base disturbance.
What this interaction means in plain words
Dichlorphenamide and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium loss and acidosis through carbonic anhydrase inhibition and tenofovir-related proximal tubular dysfunction.
What to do
Check serum potassium, bicarbonate and phosphate at baseline and periodically. Replace potassium as needed and reassess therapy if tubular dysfunction develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Tenofovir disoproxil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Dichlorphenamide and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly lowers serum potassium and causes metabolic acidosis, and tenofovir tubulopathy can also cause potassium and phosphate wasting. The combination may therefore worsen hypokalemia and acid-base disturbance.
How serious is the interaction between Dichlorphenamide and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium, bicarbonate and phosphate at baseline and periodically. Replace potassium as needed and reassess therapy if tubular dysfunction develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
