Drug interactions
Dienogest / estradiol valerate + Hydrocortisone
Severity: Minor
Dienogest / estradiol valerate and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is not a clinically relevant enzyme inducer, so loss of contraceptive efficacy is not expected. Estrogens can increase corticosteroid exposure by raising binding globulin levels.
What this interaction means in plain words
Dienogest / estradiol valerate and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens raise cortisol-binding globulin and may reduce corticosteroid clearance; hydrocortisone has no meaningful induction effect.
What to do
No back-up contraception is needed because of hydrocortisone. Monitor corticosteroid response when starting or stopping the estrogen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Hydrocortisone?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is not a clinically relevant enzyme inducer, so loss of contraceptive efficacy is not expected. Estrogens can increase corticosteroid exposure by raising binding globulin levels.
How serious is the interaction between Dienogest / estradiol valerate and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No back-up contraception is needed because of hydrocortisone. Monitor corticosteroid response when starting or stopping the estrogen.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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