Drug interactions
Dienogest / estradiol valerate + Isoniazid
Severity: Minor
Dienogest / estradiol valerate and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor in vitro, and a meaningful rise in estradiol or dienogest exposure is not well documented. Any effect is likely small and would show up as estrogen or progestogen adverse effects such as breast tenderness, nausea, headache or breakthrough bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP3A4-mediated metabolism of estradiol and dienogest by isoniazid.
What to do
No dose change is needed. Ask the patient to report breast tenderness, headache or irregular bleeding and review the contraceptive or hormone regimen if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Dienogest / estradiol valerate with Isoniazid?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor in vitro, and a meaningful rise in estradiol or dienogest exposure is not well documented. Any effect is likely small and would show up as estrogen or progestogen adverse effects such as breast tenderness, nausea, headache or breakthrough bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Ask the patient to report breast tenderness, headache or irregular bleeding and review the contraceptive or hormone regimen if these occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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