Drug interactions
Dienogest / estradiol valerate + Lamotrigine
Severity: Moderate
Dienogest / estradiol valerate and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing hormonal products can substantially lower lamotrigine concentrations. This may cause breakthrough seizures or mood relapse, and levels may rise when the estrogen is stopped, such as during pill-free weeks.
What this interaction means in plain words
Dienogest / estradiol valerate and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen induces UGT-mediated glucuronidation of lamotrigine, increasing its clearance.
What to do
Monitor lamotrigine response or levels and increase the dose as needed when starting the product. Reduce the dose again if the estrogen is stopped to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dienogest / estradiol valerate and Lamotrigine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lamotrigine
Frequently asked questions
Can I take Dienogest / estradiol valerate with Lamotrigine?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogen-containing hormonal products can substantially lower lamotrigine concentrations. This may cause breakthrough seizures or mood relapse, and levels may rise when the estrogen is stopped, such as during pill-free weeks.
How serious is the interaction between Dienogest / estradiol valerate and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lamotrigine response or levels and increase the dose as needed when starting the product. Reduce the dose again if the estrogen is stopped to avoid toxicity.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
