Drug interactions
Dienogest / estradiol valerate + Metformin-sitagliptin
Severity: Minor
Dienogest / estradiol valerate and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen and progestin combinations may alter insulin sensitivity and reduce glycemic control in some patients. The effect is typically small with modern formulations.
What this interaction means in plain words
Dienogest / estradiol valerate and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sex steroid effects on insulin sensitivity and glucose tolerance may oppose antidiabetic effect.
What to do
Monitor blood glucose after starting or stopping the combination and adjust antidiabetic treatment if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Dienogest / estradiol valerate with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen and progestin combinations may alter insulin sensitivity and reduce glycemic control in some patients. The effect is typically small with modern formulations.
How serious is the interaction between Dienogest / estradiol valerate and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the combination and adjust antidiabetic treatment if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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