Drug interactions
Dienogest / estradiol valerate + Somatropin
Severity: Moderate
Dienogest / estradiol valerate and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens suppress hepatic IGF-1 production in response to growth hormone, blunting the effect of somatropin. Patients may need a higher somatropin dose to reach the target IGF-1 level.
What this interaction means in plain words
Dienogest / estradiol valerate and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Oral estrogen reduces hepatic growth hormone signaling and IGF-1 generation through first-pass hepatic exposure.
What to do
Monitor IGF-1 and clinical response, and increase the somatropin dose if needed; a transdermal estrogen is an alternative that avoids this effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Dienogest / estradiol valerate with Somatropin?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens suppress hepatic IGF-1 production in response to growth hormone, blunting the effect of somatropin. Patients may need a higher somatropin dose to reach the target IGF-1 level.
How serious is the interaction between Dienogest / estradiol valerate and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-1 and clinical response, and increase the somatropin dose if needed; a transdermal estrogen is an alternative that avoids this effect.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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