Drug interactions
Dihydroergotamine intranasal + Venlafaxine
Severity: Moderate
Dihydroergotamine intranasal and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine has serotonin receptor agonist activity and may contribute to serotonin toxicity when combined with venlafaxine. The reported risk is low, though it deserves awareness in patients on multiple serotonergic drugs.
What this interaction means in plain words
Dihydroergotamine intranasal and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from serotonin reuptake inhibition and 5-HT receptor agonism.
What to do
Monitor for signs of serotonin syndrome and advise patients to report agitation, tremor or fever after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Venlafaxine?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal dihydroergotamine has serotonin receptor agonist activity and may contribute to serotonin toxicity when combined with venlafaxine. The reported risk is low, though it deserves awareness in patients on multiple serotonergic drugs.
How serious is the interaction between Dihydroergotamine intranasal and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and advise patients to report agitation, tremor or fever after dosing.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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