Drug interactions
Diltiazem + Doxorubicin liposomal
Severity: Moderate
Diltiazem and Doxorubicin liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase doxorubicin exposure and could add to cardiotoxicity or myelosuppression. The effect is less established for the liposomal formulation.
What this interaction means in plain words
Diltiazem and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by diltiazem may reduce doxorubicin clearance.
What to do
Monitor blood counts and cardiac function, and consider an alternative to diltiazem if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Doxorubicin liposomal?
MediHelp rates the interaction as moderate. Diltiazem and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase doxorubicin exposure and could add to cardiotoxicity or myelosuppression. The effect is less established for the liposomal formulation.
How serious is the interaction between Diltiazem and Doxorubicin liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider an alternative to diltiazem if feasible.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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