Drug interactions
Diltiazem + Encorafenib
Severity: Major
Diltiazem and Encorafenib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase encorafenib exposure, raising the risk of toxicity including QTc prolongation, dermatologic and hepatic effects.
What this interaction means in plain words
Diltiazem and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diltiazem belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Diltiazem inhibits CYP3A4, the main metabolic pathway of encorafenib.
What to do
Prefer an alternative to diltiazem. If unavoidable, reduce the encorafenib dose by about half and monitor ECG and electrolytes, then restore the dose after stopping diltiazem for several half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Diltiazem with Encorafenib?
MediHelp rates the interaction as major. Diltiazem and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diltiazem may increase encorafenib exposure, raising the risk of toxicity including QTc prolongation, dermatologic and hepatic effects.
How serious is the interaction between Diltiazem and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to diltiazem. If unavoidable, reduce the encorafenib dose by about half and monitor ECG and electrolytes, then restore the dose after stopping diltiazem for several half-lives.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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