Drug interactions
Diltiazem + Fexinidazole
Severity: Moderate
Diltiazem and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise diltiazem concentrations, increasing the risk of bradycardia, AV block and hypotension. Fexinidazole itself also prolongs the QT interval.
What this interaction means in plain words
Diltiazem and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing diltiazem metabolism.
What to do
Monitor heart rate, blood pressure and ECG during the short fexinidazole course. Reduce the diltiazem dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Fexinidazole?
MediHelp rates the interaction as moderate. Diltiazem and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise diltiazem concentrations, increasing the risk of bradycardia, AV block and hypotension. Fexinidazole itself also prolongs the QT interval.
How serious is the interaction between Diltiazem and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during the short fexinidazole course. Reduce the diltiazem dose if bradycardia or hypotension develops.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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