Drug interactions
Diltiazem + Glimepiride-pioglitazone
Severity: Minor
Diltiazem and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4, one of the enzymes involved in pioglitazone metabolism, and may modestly raise pioglitazone exposure. The clinical effect is usually small, but adverse effects such as edema or hypoglycemia could be more likely.
What this interaction means in plain words
Diltiazem and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Diltiazem inhibits CYP3A4-mediated metabolism of pioglitazone, which is also metabolized by CYP2C8.
What to do
No routine dose change is needed; monitor glucose and for edema when diltiazem is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diltiazem and Glimepiride-pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride-pioglitazone
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Diltiazem and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem inhibits CYP3A4, one of the enzymes involved in pioglitazone metabolism, and may modestly raise pioglitazone exposure. The clinical effect is usually small, but adverse effects such as edema or hypoglycemia could be more likely.
How serious is the interaction between Diltiazem and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glucose and for edema when diltiazem is started or stopped.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
