Drug interactions
Diltiazem + Hydrocortisone
Severity: Minor
Diltiazem and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and may modestly raise hydrocortisone exposure, which is mainly relevant with long-term or high-dose use. Cushingoid effects or adrenal suppression are possible but usually mild.
What this interaction means in plain words
Diltiazem and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Moderate CYP3A4 inhibition by diltiazem reducing corticosteroid clearance.
What to do
No routine change needed; watch for steroid excess such as fluid retention or hyperglycemia during long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Hydrocortisone?
MediHelp rates the interaction as minor. Diltiazem and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem inhibits CYP3A4 and may modestly raise hydrocortisone exposure, which is mainly relevant with long-term or high-dose use. Cushingoid effects or adrenal suppression are possible but usually mild.
How serious is the interaction between Diltiazem and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; watch for steroid excess such as fluid retention or hyperglycemia during long-term therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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