Drug interactions
Diltiazem + Infigratinib
Severity: Moderate
Diltiazem and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase infigratinib exposure and its toxicities such as hyperphosphatemia, ocular and nail effects.
What this interaction means in plain words
Diltiazem and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diltiazem inhibits CYP3A4, which is the main metabolic pathway of infigratinib.
What to do
Prefer an alternative to diltiazem. If used, monitor for infigratinib toxicity and consider dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Infigratinib?
MediHelp rates the interaction as moderate. Diltiazem and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase infigratinib exposure and its toxicities such as hyperphosphatemia, ocular and nail effects.
How serious is the interaction between Diltiazem and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to diltiazem. If used, monitor for infigratinib toxicity and consider dose reduction.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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