Drug interactions
Diltiazem + Ixabepilone
Severity: Moderate
Diltiazem and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is metabolized by CYP3A4, and diltiazem may raise its exposure, increasing neutropenia and neuropathy. The label recommends dose reduction with strong inhibitors, and moderate inhibitors warrant caution.
What this interaction means in plain words
Diltiazem and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diltiazem inhibits CYP3A4-mediated clearance of ixabepilone.
What to do
Monitor blood counts and neuropathy symptoms, or use a non-CYP3A4-inhibiting alternative to diltiazem where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Ixabepilone?
MediHelp rates the interaction as moderate. Diltiazem and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is metabolized by CYP3A4, and diltiazem may raise its exposure, increasing neutropenia and neuropathy. The label recommends dose reduction with strong inhibitors, and moderate inhibitors warrant caution.
How serious is the interaction between Diltiazem and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms, or use a non-CYP3A4-inhibiting alternative to diltiazem where possible.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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