Drug interactions
Diltiazem + Lumefantrine
Severity: Moderate
Diltiazem and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4 and diltiazem may raise its levels, adding to QT prolongation risk. Lumefantrine may have an effect on diltiazem metabolism, though this is uncertain.
What this interaction means in plain words
Diltiazem and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of lumefantrine.
What to do
Consider baseline ECG and avoid other QT-prolonging drugs, and monitor heart rate and blood pressure during the antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Lumefantrine?
MediHelp rates the interaction as moderate. Diltiazem and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is metabolized by CYP3A4 and diltiazem may raise its levels, adding to QT prolongation risk. Lumefantrine may have an effect on diltiazem metabolism, though this is uncertain.
How serious is the interaction between Diltiazem and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline ECG and avoid other QT-prolonging drugs, and monitor heart rate and blood pressure during the antimalarial course.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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