Drug interactions
Diltiazem + Magnesium supplement
Severity: Moderate
Diltiazem and Magnesium supplement: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has calcium-antagonist properties, and in combination with calcium channel blockers it may increase hypotension. Neuromuscular blockade has been reported with parenteral magnesium given with calcium channel blockers. Oral supplements pose less risk.
What this interaction means in plain words
Diltiazem and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive calcium antagonism and vasodilatory effects.
What to do
Monitor blood pressure and neuromuscular function, particularly with intravenous magnesium. Oral supplementation at usual doses generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Magnesium supplement?
MediHelp rates the interaction as moderate. Diltiazem and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium has calcium-antagonist properties, and in combination with calcium channel blockers it may increase hypotension. Neuromuscular blockade has been reported with parenteral magnesium given with calcium channel blockers. Oral supplements pose less risk.
How serious is the interaction between Diltiazem and Magnesium supplement?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and neuromuscular function, particularly with intravenous magnesium. Oral supplementation at usual doses generally needs no change.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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