Drug interactions
Diltiazem + Metformin-sitagliptin
Severity: Minor
Diltiazem and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as diltiazem may modestly worsen glucose control in some patients taking metformin. Diltiazem may also raise metformin levels slightly.
What this interaction means in plain words
Diltiazem and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Possible reduction in insulin release and tissue sensitivity; possible OCT-related effects on metformin disposition.
What to do
Monitor blood glucose when starting or stopping diltiazem. Adjust antidiabetic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Diltiazem and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers such as diltiazem may modestly worsen glucose control in some patients taking metformin. Diltiazem may also raise metformin levels slightly.
How serious is the interaction between Diltiazem and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diltiazem. Adjust antidiabetic dose if needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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