Drug interactions
Diltiazem + Metipranolol
Severity: Minor
Diltiazem and Metipranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol is a nonselective beta blocker given as eye drops, but some drug is absorbed systemically. With diltiazem, which slows sinus and AV node conduction, there is a possibility of additive bradycardia, AV block or hypotension, especially in susceptible patients.
What this interaction means in plain words
Diltiazem and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive negative chronotropic and dromotropic effects from beta blockade and calcium channel blockade.
What to do
Monitor heart rate and ECG in patients with conduction disease or on high-dose diltiazem when starting metipranolol drops. Use punctal occlusion to reduce systemic absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Metipranolol?
MediHelp rates the interaction as minor. Diltiazem and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metipranolol is a nonselective beta blocker given as eye drops, but some drug is absorbed systemically. With diltiazem, which slows sinus and AV node conduction, there is a possibility of additive bradycardia, AV block or hypotension, especially in susceptible patients.
How serious is the interaction between Diltiazem and Metipranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction disease or on high-dose diltiazem when starting metipranolol drops. Use punctal occlusion to reduce systemic absorption.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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