Drug interactions
Diltiazem + Nitroprusside
Severity: Moderate
Diltiazem and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so combined use can produce a greater fall than expected. This is usually predictable in monitored settings but can cause excessive hypotension.
What this interaction means in plain words
Diltiazem and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and hypotensive effects.
What to do
Titrate nitroprusside infusion against continuous blood pressure monitoring and use lower infusion rates if the patient is on diltiazem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Nitroprusside?
MediHelp rates the interaction as moderate. Diltiazem and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so combined use can produce a greater fall than expected. This is usually predictable in monitored settings but can cause excessive hypotension.
How serious is the interaction between Diltiazem and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate nitroprusside infusion against continuous blood pressure monitoring and use lower infusion rates if the patient is on diltiazem.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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