Drug interactions
Diltiazem + Olanzapine / samidorphan
Severity: Moderate
Diltiazem and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering effect of diltiazem. Patients may experience dizziness, falls or syncope, especially when starting treatment or increasing doses.
What this interaction means in plain words
Diltiazem and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects through alpha-adrenergic blockade by olanzapine and calcium channel blockade by diltiazem.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the antihypertensive dose if hypotension occurs. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Diltiazem and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering effect of diltiazem. Patients may experience dizziness, falls or syncope, especially when starting treatment or increasing doses.
How serious is the interaction between Diltiazem and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the antihypertensive dose if hypotension occurs. Counsel patients to rise slowly.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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