Drug interactions
Diltiazem + Paclitaxel protein bound
Severity: Moderate
Diltiazem and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, so diltiazem may raise its exposure. This could increase myelosuppression, neuropathy, mucositis and diarrhea.
What this interaction means in plain words
Diltiazem and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diltiazem inhibits CYP3A4 (and possibly P-glycoprotein), reducing paclitaxel clearance.
What to do
Monitor blood counts and signs of neuropathy and mucositis, and reduce or delay paclitaxel doses as per toxicity guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Diltiazem and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8 and CYP3A4, so diltiazem may raise its exposure. This could increase myelosuppression, neuropathy, mucositis and diarrhea.
How serious is the interaction between Diltiazem and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy and mucositis, and reduce or delay paclitaxel doses as per toxicity guidance.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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