Drug interactions
Diltiazem + Phendimetrazine
Severity: Moderate
Diltiazem and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate, opposing diltiazem's antihypertensive and rate-controlling effects.
What this interaction means in plain words
Diltiazem and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through sympathomimetic pressor effects.
What to do
Monitor blood pressure and heart rate and adjust antihypertensive therapy if control is lost. Avoid the anorectic in uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Phendimetrazine?
MediHelp rates the interaction as moderate. Diltiazem and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate, opposing diltiazem's antihypertensive and rate-controlling effects.
How serious is the interaction between Diltiazem and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust antihypertensive therapy if control is lost. Avoid the anorectic in uncontrolled hypertension.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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