Drug interactions
Diltiazem + Rapacuronium
Severity: Moderate
Diltiazem and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can potentiate nondepolarizing neuromuscular blockers, prolonging or deepening neuromuscular blockade. Rapacuronium has been withdrawn from the market, so the pair is mainly of historical relevance.
What this interaction means in plain words
Diltiazem and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces prejunctional acetylcholine release, augmenting nondepolarizing neuromuscular blockade.
What to do
If diltiazem is used with any nondepolarizing blocker, monitor neuromuscular function with a nerve stimulator and reduce dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Rapacuronium?
MediHelp rates the interaction as moderate. Diltiazem and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can potentiate nondepolarizing neuromuscular blockers, prolonging or deepening neuromuscular blockade. Rapacuronium has been withdrawn from the market, so the pair is mainly of historical relevance.
How serious is the interaction between Diltiazem and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If diltiazem is used with any nondepolarizing blocker, monitor neuromuscular function with a nerve stimulator and reduce dosing as needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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