Drug interactions
Diltiazem + Sodium nitroprusside
Severity: Moderate
Diltiazem and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem adds to nitroprusside vasodilation and may cause excessive hypotension. Its negative chronotropic effect may reduce compensatory tachycardia.
What this interaction means in plain words
Diltiazem and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive vasodilation via calcium channel blockade and nitric oxide-mediated relaxation.
What to do
Monitor arterial pressure and heart rate continuously and titrate the nitroprusside dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Diltiazem and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem adds to nitroprusside vasodilation and may cause excessive hypotension. Its negative chronotropic effect may reduce compensatory tachycardia.
How serious is the interaction between Diltiazem and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arterial pressure and heart rate continuously and titrate the nitroprusside dose to response.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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