Drug interactions
Diltiazem + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Minor
Diltiazem and Sodium sulfate / ?magnesium sulfate / potassium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium is a physiological calcium antagonist, and elevated serum magnesium with a calcium channel blocker may cause additive hypotension and neuromuscular weakness. With oral bowel preparations, significant absorption is uncommon but possible in renal impairment.
What this interaction means in plain words
Diltiazem and Sodium sulfate / ?magnesium sulfate / potassium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive calcium antagonism and vasodilation from hypermagnesemia combined with calcium channel blockade.
What to do
In patients with renal impairment, check serum magnesium and monitor blood pressure and muscle strength. Maintain hydration during bowel preparation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as minor. Diltiazem and Sodium sulfate / ?magnesium sulfate / potassium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium is a physiological calcium antagonist, and elevated serum magnesium with a calcium channel blocker may cause additive hypotension and neuromuscular weakness. With oral bowel preparations, significant absorption is uncommon but possible in renal impairment.
How serious is the interaction between Diltiazem and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with renal impairment, check serum magnesium and monitor blood pressure and muscle strength. Maintain hydration during bowel preparation.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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