Drug interactions
Diltiazem + Topiramate
Severity: Minor
Diltiazem and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate has weak enzyme-inducing effects, and a small reduction in diltiazem exposure has been reported. Clinical impact is usually limited.
What this interaction means in plain words
Diltiazem and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Topiramate belongs to Central Nervous System.
Why it happens
Topiramate weakly induces CYP3A4, increasing diltiazem metabolism.
What to do
Monitor blood pressure and heart rate and adjust the diltiazem dose only if the response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Topiramate
Frequently asked questions
Can I take Diltiazem with Topiramate?
MediHelp rates the interaction as minor. Diltiazem and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate has weak enzyme-inducing effects, and a small reduction in diltiazem exposure has been reported. Clinical impact is usually limited.
How serious is the interaction between Diltiazem and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust the diltiazem dose only if the response is reduced.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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