Drug interactions
Diltiazem + Triamcinolone acetonide injectable
Severity: Moderate
Diltiazem and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may reduce the clearance of triamcinolone and raise systemic corticosteroid exposure. With repeated or high-dose injections this may cause Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Diltiazem and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated triamcinolone metabolism by diltiazem.
What to do
Use the lowest effective triamcinolone dose and avoid frequent repeat injections. Monitor for signs of corticosteroid excess such as hyperglycemia, fluid retention and hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diltiazem and Triamcinolone acetonide injectable, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Diltiazem and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may reduce the clearance of triamcinolone and raise systemic corticosteroid exposure. With repeated or high-dose injections this may cause Cushingoid effects and adrenal suppression.
How serious is the interaction between Diltiazem and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triamcinolone dose and avoid frequent repeat injections. Monitor for signs of corticosteroid excess such as hyperglycemia, fluid retention and hypertension.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
