Drug interactions
Diltiazem + Triazolam
Severity: Major
Diltiazem and Triazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem markedly raises triazolam concentrations and prolongs its effects. This increases sedation, psychomotor impairment, amnesia and the risk of falls.
What this interaction means in plain words
Diltiazem and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Diltiazem inhibits intestinal and hepatic CYP3A4, reducing triazolam first-pass and systemic clearance.
What to do
Use a reduced triazolam dose or switch to a benzodiazepine not dependent on CYP3A4, such as temazepam or lorazepam. Monitor for excessive sedation and impaired psychomotor function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Triazolam?
MediHelp rates the interaction as major. Diltiazem and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diltiazem markedly raises triazolam concentrations and prolongs its effects. This increases sedation, psychomotor impairment, amnesia and the risk of falls.
How serious is the interaction between Diltiazem and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced triazolam dose or switch to a benzodiazepine not dependent on CYP3A4, such as temazepam or lorazepam. Monitor for excessive sedation and impaired psychomotor function.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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