Drug interactions
Diltiazem + Trimagnesium
Severity: Minor
Diltiazem and Trimagnesium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium can have calcium-antagonist effects and may add to the hypotensive and neuromuscular effects of calcium channel blockers. Clinically significant interaction is uncommon with oral magnesium salts, but hypotension or weakness can occur, particularly with parenteral magnesium.
What this interaction means in plain words
Diltiazem and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic calcium-channel antagonism and vasodilation.
What to do
Monitor blood pressure and for muscle weakness when magnesium is given in high or parenteral doses. No routine dose change is needed for usual oral doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Trimagnesium?
MediHelp rates the interaction as minor. Diltiazem and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium can have calcium-antagonist effects and may add to the hypotensive and neuromuscular effects of calcium channel blockers. Clinically significant interaction is uncommon with oral magnesium salts, but hypotension or weakness can occur, particularly with parenteral magnesium.
How serious is the interaction between Diltiazem and Trimagnesium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for muscle weakness when magnesium is given in high or parenteral doses. No routine dose change is needed for usual oral doses.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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