Drug interactions
Diltiazem + Vincristine liposomal
Severity: Major
Diltiazem and Vincristine liposomal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may reduce vincristine metabolism and raise its exposure. This may increase neurotoxicity, including peripheral neuropathy and constipation or ileus.
What this interaction means in plain words
Diltiazem and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 and possibly P-glycoprotein by diltiazem reduces vincristine clearance.
What to do
Where possible use an alternative to diltiazem that does not inhibit CYP3A4. If the combination is needed, monitor closely for neuropathy and bowel dysfunction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Vincristine liposomal?
MediHelp rates the interaction as major. Diltiazem and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diltiazem may reduce vincristine metabolism and raise its exposure. This may increase neurotoxicity, including peripheral neuropathy and constipation or ileus.
How serious is the interaction between Diltiazem and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible use an alternative to diltiazem that does not inhibit CYP3A4. If the combination is needed, monitor closely for neuropathy and bowel dysfunction.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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