Drug interactions
Diltiazem + Xipamide
Severity: Moderate
Diltiazem and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering effect of diltiazem. This is often intended in hypertension, but may cause excessive hypotension or dizziness, and diuretic-induced electrolyte disturbances may affect cardiac conduction.
What this interaction means in plain words
Diltiazem and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects from vasodilation and diuresis.
What to do
Monitor blood pressure and heart rate, and check potassium and magnesium periodically. Adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Xipamide?
MediHelp rates the interaction as moderate. Diltiazem and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering effect of diltiazem. This is often intended in hypertension, but may cause excessive hypotension or dizziness, and diuretic-induced electrolyte disturbances may affect cardiac conduction.
How serious is the interaction between Diltiazem and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and check potassium and magnesium periodically. Adjust doses if symptomatic hypotension develops.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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