Drug interactions
Diltiazem + Zanubrutinib
Severity: Moderate
Diltiazem and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem raises zanubrutinib exposure, which may increase bleeding, cytopenias and infection risk and other adverse reactions.
What this interaction means in plain words
Diltiazem and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of zanubrutinib by diltiazem.
What to do
Reduce zanubrutinib to 80 mg twice daily during coadministration and monitor for toxicity, resuming the usual dose after diltiazem is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Diltiazem with Zanubrutinib?
MediHelp rates the interaction as moderate. Diltiazem and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem raises zanubrutinib exposure, which may increase bleeding, cytopenias and infection risk and other adverse reactions.
How serious is the interaction between Diltiazem and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg twice daily during coadministration and monitor for toxicity, resuming the usual dose after diltiazem is stopped.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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