Drug interactions
Diphenhydramine + Echothiophate iodide
Severity: Minor
Diphenhydramine and Echothiophate iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an irreversible cholinesterase inhibitor used in the eye, while diphenhydramine has anticholinergic activity that opposes cholinergic stimulation. Any interaction is likely small because the ophthalmic dose has little systemic absorption.
What this interaction means in plain words
Diphenhydramine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between cholinesterase inhibition and muscarinic blockade.
What to do
No routine adjustment is needed. Be alert for reduced effect of echothiophate on pupil constriction or intraocular pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Echothiophate iodide?
MediHelp rates the interaction as minor. Diphenhydramine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echothiophate is an irreversible cholinesterase inhibitor used in the eye, while diphenhydramine has anticholinergic activity that opposes cholinergic stimulation. Any interaction is likely small because the ophthalmic dose has little systemic absorption.
How serious is the interaction between Diphenhydramine and Echothiophate iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be alert for reduced effect of echothiophate on pupil constriction or intraocular pressure.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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