Drug interactions
Diphenhydramine + Esketamine intranasal
Severity: Moderate
Diphenhydramine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and diphenhydramine adds further sedating effects. The combination may deepen drowsiness and impair alertness after dosing.
What this interaction means in plain words
Diphenhydramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation during the post-dose observation period and avoid giving diphenhydramine around esketamine sessions. Advise against driving until the next day after restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Diphenhydramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and diphenhydramine adds further sedating effects. The combination may deepen drowsiness and impair alertness after dosing.
How serious is the interaction between Diphenhydramine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during the post-dose observation period and avoid giving diphenhydramine around esketamine sessions. Advise against driving until the next day after restful sleep.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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