Drug interactions
Diphenhydramine + Glycopyrronium tosylate
Severity: Moderate
Diphenhydramine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can cause systemic anticholinergic effects. Together with oral diphenhydramine, effects such as dry mouth, urinary hesitancy and blurred vision may be additive.
What this interaction means in plain words
Diphenhydramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic symptoms and stop the topical agent if they become troublesome. Avoid in patients with glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Diphenhydramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can cause systemic anticholinergic effects. Together with oral diphenhydramine, effects such as dry mouth, urinary hesitancy and blurred vision may be additive.
How serious is the interaction between Diphenhydramine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and stop the topical agent if they become troublesome. Avoid in patients with glaucoma or urinary retention.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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