Drug interactions
Diphenhydramine + Hops
Severity: Minor
Diphenhydramine and Hops: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hops is used as a mild herbal sedative, so combined use with diphenhydramine may increase drowsiness. Evidence is limited and the effect is probably small.
What this interaction means in plain words
Diphenhydramine and Hops have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the sedative mechanism of hops is not fully established.
What to do
Counsel patients about additive drowsiness and caution when driving. Stop the herbal product if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Hops?
MediHelp rates the interaction as minor. Diphenhydramine and Hops have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hops is used as a mild herbal sedative, so combined use with diphenhydramine may increase drowsiness. Evidence is limited and the effect is probably small.
How serious is the interaction between Diphenhydramine and Hops?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution when driving. Stop the herbal product if excess sedation occurs.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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