Drug interactions
Diphenhydramine + Sage
Severity: Minor
Diphenhydramine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage is reported to have mild sedative properties, so combining it with a sedating antihistamine could increase drowsiness. The clinical significance is likely small and the evidence is largely theoretical.
What this interaction means in plain words
Diphenhydramine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effect; the mechanism for sage is not firmly established.
What to do
Advise patients to watch for increased drowsiness and avoid driving if affected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Sage?
MediHelp rates the interaction as minor. Diphenhydramine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage is reported to have mild sedative properties, so combining it with a sedating antihistamine could increase drowsiness. The clinical significance is likely small and the evidence is largely theoretical.
How serious is the interaction between Diphenhydramine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for increased drowsiness and avoid driving if affected.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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