Drug interactions
Diphenhydramine + Scullcap
Severity: Minor
Diphenhydramine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal products are traditionally used as mild sedatives and may add to the drowsiness caused by diphenhydramine. Evidence is limited and product content varies.
What this interaction means in plain words
Diphenhydramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the herb's mechanism is poorly defined.
What to do
Advise patients to avoid driving until they know how the combination affects them. Avoid the herbal product when alertness is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Scullcap?
MediHelp rates the interaction as minor. Diphenhydramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap herbal products are traditionally used as mild sedatives and may add to the drowsiness caused by diphenhydramine. Evidence is limited and product content varies.
How serious is the interaction between Diphenhydramine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving until they know how the combination affects them. Avoid the herbal product when alertness is needed.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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