Drug interactions
Diphenhydramine + Triazolam
Severity: Moderate
Diphenhydramine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen drowsiness and slow reaction time. Impairment of memory, coordination and next-day alertness may be greater than with either drug alone, particularly in older adults.
What this interaction means in plain words
Diphenhydramine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1-antihistamine sedation and benzodiazepine GABA-A potentiation.
What to do
Avoid combining as sleep aids where possible and counsel on driving and fall risk. Use the lowest effective triazolam dose and monitor older patients for excess sedation and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Triazolam?
MediHelp rates the interaction as moderate. Diphenhydramine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen drowsiness and slow reaction time. Impairment of memory, coordination and next-day alertness may be greater than with either drug alone, particularly in older adults.
How serious is the interaction between Diphenhydramine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining as sleep aids where possible and counsel on driving and fall risk. Use the lowest effective triazolam dose and monitor older patients for excess sedation and confusion.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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