Drug interactions
Diphenhydramine + Triclofos
Severity: Moderate
Diphenhydramine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite, trichloroethanol, depresses the CNS. Adding a sedating antihistamine can cause excessive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression.
What this interaction means in plain words
Diphenhydramine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between a sedating H1-antihistamine and a chloral-derivative hypnotic.
What to do
Avoid concurrent use when possible, and reduce the triclofos dose if both are required. Monitor sedation level, particularly in children and older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Triclofos?
MediHelp rates the interaction as moderate. Diphenhydramine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite, trichloroethanol, depresses the CNS. Adding a sedating antihistamine can cause excessive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression.
How serious is the interaction between Diphenhydramine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible, and reduce the triclofos dose if both are required. Monitor sedation level, particularly in children and older adults.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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