Drug interactions
Diphenhydramine + Valerian
Severity: Minor
Diphenhydramine and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may increase the drowsiness caused by diphenhydramine. Psychomotor impairment may be more pronounced, though documented clinical data are limited.
What this interaction means in plain words
Diphenhydramine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probable additive CNS depression, with valerian acting through GABAergic pathways.
What to do
Advise patients about increased drowsiness and caution with driving or machinery. Avoid using both together as sleep aids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Valerian?
MediHelp rates the interaction as minor. Diphenhydramine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has sedative properties and may increase the drowsiness caused by diphenhydramine. Psychomotor impairment may be more pronounced, though documented clinical data are limited.
How serious is the interaction between Diphenhydramine and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about increased drowsiness and caution with driving or machinery. Avoid using both together as sleep aids.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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