Drug interactions
Diphenhydramine + Yohimbine
Severity: Minor
Diphenhydramine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine causes sedation whereas yohimbine is an alpha-2 antagonist with stimulant effects, so their effects may partly oppose each other. The result is unpredictable and no clinically important interaction is well established.
What this interaction means in plain words
Diphenhydramine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic mechanism.
What to do
No routine adjustment is needed. Monitor for changes in sedation or anxiety and for tachycardia or hypertension from yohimbine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenhydramine
Frequently asked questions
Can I take Diphenhydramine with Yohimbine?
MediHelp rates the interaction as minor. Diphenhydramine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine causes sedation whereas yohimbine is an alpha-2 antagonist with stimulant effects, so their effects may partly oppose each other. The result is unpredictable and no clinically important interaction is well established.
How serious is the interaction between Diphenhydramine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for changes in sedation or anxiety and for tachycardia or hypertension from yohimbine.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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