Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine + Methotrexate
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may lessen the immune response to this inactivated combination vaccine. The vaccine itself is non-live and may be given, but protection may be lower.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Methotrexate impairs lymphocyte proliferation and so reduces vaccine immune response.
What to do
Vaccinate according to schedule and consider checking serologic response where protection is essential.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine with Methotrexate?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methotrexate may lessen the immune response to this inactivated combination vaccine. The vaccine itself is non-live and may be given, but protection may be lower.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule and consider checking serologic response where protection is essential.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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