Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Methotrexate
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may blunt the antibody response to this inactivated combined vaccine. Protection may be reduced, although the vaccine remains safe in immunosuppressed patients.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Methotrexate impairs lymphocyte proliferation and so reduces vaccine immune response.
What to do
Vaccinate on schedule rather than withholding the vaccine. Consider timing doses to periods of lower immunosuppression when feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Methotrexate?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methotrexate may blunt the antibody response to this inactivated combined vaccine. Protection may be reduced, although the vaccine remains safe in immunosuppressed patients.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule rather than withholding the vaccine. Consider timing doses to periods of lower immunosuppression when feasible.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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